One-year follow-up of mild traumatic brain injury:: Post-concussion symptoms, disabilities and life satisfaction in relation to serum levels of S-100B and neurone-specific enolase in acute phase

被引:84
作者
Stålnacke, BM
Björnstig, U
Karlsson, K
Sojka, P
机构
[1] Umea Univ, Univ Umea Hosp, Dept Community Med & Rehabil, SE-90185 Umea, Sweden
[2] Univ Umea Hosp, Dept Surg & Perioperat Sci, SE-90185 Umea, Sweden
[3] Univ Umea Hosp, Sect Surg, SE-90185 Umea, Sweden
[4] Univ Umea Hosp, Dept Med Biosci Clin Chem, SE-90185 Umea, Sweden
关键词
traumatic brain injury; head trauma; brain concussion; biochemical marker; S-100; proteins; life satisfaction; post-concussion symptoms;
D O I
10.1080/16501970510032910
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
Objective: To investigate, in patients with mild traumatic brain injury, serum concentrations of S-100B and neurone-specific enolase in acute phase and post-concussion symptoms, disabilities and life satisfaction 1 year after the trauma. Design: Prospective study. Patients: Eighty-eight patients (age range 18-87 years). Methods: Blood samples were taken on admission and about 7 hours later. At follow-up 15 4 months later, the patients filled in questionnaires about symptoms (Rivermead Post Concussion Symptoms), disability (Rivermead Head Injury Follow-up) and life satisfaction (LiSat-11). Results: Concentrations of S-100B and neurone-specific enolase were regularly increased in the first blood sample. Of the 69 patients participating in the follow-up, 45% reported post-concussion symptom, 48% exhibited disability and 55% were satisfied with "life as a whole". In comparison with the "sick-leave" situation on admission to hospital, 3 patients were on sick-leave at the time of follow-up because of the head trauma. Stepwise forward logistic regression analysis revealed a statistically significant association (p<0.05) between disability and S-100B and dizziness. Conclusion: In spite of frequent persistent symptoms, disabilities and low levels of life satisfaction, the sick-leave frequency was low at follow-up. The association between S-100B and disability supports the notion that long-term consequences of a mild brain injury may partly be a result of brain tissue injury.
引用
收藏
页码:300 / 305
页数:6
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