Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases

被引：57

作者：

Nanahoshi, M

Tsujishita, Y

Tokunaga, C

Inui, S

Sakaguchi, N

Hara, K

Yonezawa, K

机构：

[1] Kobe Univ, Biosignal Res Ctr, Kobe, Hyogo 6578501, Japan

[2] Kumamoto Univ, Sch Med, Dept Immunol, Kumamoto 8600811, Japan

来源：

FEBS LETTERS | 1999年 / 446卷 / 01期

关键词：

alpha4; protein phosphatase 2A; protein phosphatase 4; protein phosphatase 6; PR65;

D O I：

10.1016/S0014-5793(99)00189-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The catalytic activity of the C subunit of serine/threonine phosphatase 2A is regulated by the association with A (PR65) and B subunits. It has been reported that the alpha4 protein, a yeast homolog of the Tap42 protein, binds the C subunit of serine/threonine phosphatase 2A and protein phosphatase 2A-related protein phosphatases such as protein phosphatase 4 and protein phosphatase 6. In the present study, we showed that alpha4 binds these three phosphatases and the association of alpha4 reduces the activities of these phosphatases in vitro. In contrast, PR65 binds to the C subunit of serine/threonine phosphatase 2A but not to protein phosphatase 4 and protein phosphatase 6. These results suggest that the alpha4 protein is a common regulator of the C subunit of serine/threonine phosphatase 2A and protein phosphatase 2A-related protein phosphatases. (C) 1999 Federation of European Biochemical Societies.

引用

页码：108 / 112

页数：5

共 25 条

[1] Immunopharmacology of rapamycin [J].