Ras hitchhikes on PDE6δ

被引：21

作者：

Philips, Mark R. ^{[1
]}

机构：

[1] NYU, Inst Canc, New York, NY 10016 USA

来源：

NATURE CELL BIOLOGY | 2012年 / 14卷 / 02期

关键词：

DELTA-SUBUNIT; PDE-DELTA; MEMBRANE; TRANSPORT; LOCALIZATION; ASSOCIATION; ARL2-GTP; SEGMENTS; PROMOTES; PROTEIN;

D O I：

10.1038/ncb2429

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Ras GTPases are tethered to cellular membranes by a farnesyl lipid that modifies a carboxy-terminal cysteine. One of the ways Ras traffics between membranes is via fluid-phase diffusion, suggesting that a cytosolic chaperone might be needed to shield the farnesyl lipid during transport. PDE6 delta is now revealed to be a farnesyl-binding chaperone that facilitates the trafficking and signalling of Ras.

引用

收藏

页码：128 / 129

页数：2

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