Tumour necrosis factor-α does not cross the rat placenta

被引：14

作者：

Carbó, N ^{[1
]}

López-Soriano, FJ ^{[1
]}

Argilés, JM ^{[1
]}

机构：

[1] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, E-08071 Barcelona, Spain

来源：

CANCER LETTERS | 1998年 / 128卷 / 01期

关键词：

placenta; transport; TNF;

D O I：

10.1016/S0304-3835(98)00057-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the last few years there has been a considerable proliferation of studies suggesting that tumour necrosis factor-alpha (TNF) has a very important physiological role in pregnancy. Its presence in the fetus has been related to several important roles such as cell growth and differentiation or immune protection. The aim of the present work was to analyze whether maternal TNF could reach the fetal circulation. The results found after in vivo [I-125]TNF administration to pregnant rats at term demonstrate that, TNF does not cross the placenta and therefore it may be suggested that the cytokine which is found in the fetus is synthesized in its organs. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：101 / 104

页数：4

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