Conserved microtubule-actin interactions in cell movement and morphogenesis

被引：695

作者：

Rodriguez, OC

Schaefer, AW

Mandato, CA

Forscher, P

Bement, WM

Waterman-Storer, CM

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[3] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 2B2, Canada

[4] Univ Wisconsin, Dept Zool, Madison, WI 53706 USA

[5] Univ Wisconsin, Mol & Cellular Biol Program, Madison, WI 53706 USA

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 07期

关键词：

D O I：

10.1038/ncb0703-599

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interactions between microtubules and actin are a basic phenomenon that underlies many fundamental processes in which dynamic cellular asymmetries need to be established and maintained. These are processes as diverse as cell motility, neuronal pathfinding, cellular wound healing, cell division and cortical flow. Microtubules and actin exhibit two mechanistic classes of interactions - regulatory and structural. These interactions comprise at least three conserved 'mechanochemical activity modules' that perform similar roles in these diverse cell functions.

引用

页码：599 / 609

页数：11

共 112 条

[1] pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis [J].