What's taking so long? S-phase entry from quiescence versus proliferation

被引：81

作者：

Coller, Hilary A. ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Thomas Lab, Princeton, NJ 08544 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 08期

关键词：

D O I：

10.1038/nrm2223

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is a short window in the mammalian cell cycle during which cells can respond to extracellular cues by withdrawing temporarily from the cell cycle. When these cells re-enter the cell cycle, they require several extra hours in the G1 phase before they replicate their DNA compared with their cycling counterparts. More than 20 years after this initial observation, we still do not understand what is taking so long.

引用

页码：667 / 670

页数：4

共 41 条

[1] Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27(KIP1) [J].

Aktas, H ;

Cai, H ;

Cooper, GM .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (07) :3850-3857

[2] Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells [J].

Arias, Emily E. ;

Walter, Johannes C. .

GENES & DEVELOPMENT, 2007, 21 (05) :497-518

[3]

BASERGA R, 1973, FED PROC, V32, P2115

[4] Preventing re-replication of chromosomal DNA [J].

Blow, JJ ;

Dutta, A .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (06) :476-486

[5] TEMPERATURE-SENSITIVE CELL-CYCLE MUTANT OF BHK CELL LINE [J].

BURSTIN, SJ ;

MEISS, HK ;

BASILICO, C .

JOURNAL OF CELLULAR PHYSIOLOGY, 1974, 84 (03) :397-408

[6] Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1) [J].

Cheng, MG ;

Sexl, V ;

Sherr, CJ ;

Roussel, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (03) :1091-1096

[7] A new description of cellular quiescence [J].

Coller, HA ;

Sang, LY ;

Roberts, JM .

PLOS BIOLOGY, 2006, 4 (03) :329-349

[8]

COPPOCK DL, 1993, CELL GROWTH DIFFER, V4, P483

[9] Distinct roles for cyclins E and A during DNA replication complex assembly and activation [J].

Coverley, D ;

Laman, H ;

Laskey, RA .

NATURE CELL BIOLOGY, 2002, 4 (07) :523-528

[10]

DEGREGORI J, 1995, MOL CELL BIOL, V15, P4215

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