Peptide and peptidomimetic libraries - Molecular diversity and drug design

被引:16
作者
Al-Obeidi, E
Hruby, VJ
Sawyer, TK
机构
[1] Selectide Res Ctr, Tucson, AZ USA
[2] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA
[3] ARIAD Pharmaceut Inc, Drug Discovery, Cambridge, MA 02139 USA
关键词
combinatorial libraries; peptides; peptidomimetics; molecular diversity;
D O I
10.1007/BF02915794
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Various techniques for generation of peptide and peptidomimetic libraries are summarized in this article. Multipin, tea bag, and split-couple-mix techniques represent the major methods used to make peptides and peptidomimetics libraries. The synthesis of these libraries were made in either discrete or mixture format. Peptides and peptidomimetics combinatorial libraries were screened to discover leads against a variety of targets. These targets, including bacteria, fungus, virus, receptors, and enzymes were used in the screening of the libraries. Discovered leads can be further optimized by combinatorial approaches.
引用
收藏
页码:205 / 223
页数:19
相关论文
共 59 条
[1]  
ABELSON JN, 1996, METHODS ENZYMOL, V267
[2]   INHIBITORS OF HUMAN HEART CHYMASE BASED ON A PEPTIDE LIBRARY [J].
BASTOS, M ;
MAEJI, NJ ;
ABELES, RH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (15) :6738-6742
[3]   Synthetic combinatorial libraries: Novel discovery strategy for identification of antimicrobial agents [J].
Blondelle, SE ;
PerezPaya, E ;
Houghten, RA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (05) :1067-1071
[4]   Novel antimicrobial compounds identified using synthetic combinatorial library technology [J].
Blondelle, SE ;
Houghten, RA .
TRENDS IN BIOTECHNOLOGY, 1996, 14 (02) :60-65
[5]   Combinatorial peptide libraries: Robotic synthesis and analysis by nuclear magnetic resonance, mass spectrometry, tandem mass spectrometry, and high-performance capillary electrophoresis techniques [J].
Boutin, JA ;
Hennig, P ;
Lambert, PH ;
Bertin, S ;
Petit, L ;
Mahieu, JP ;
Serkiz, B ;
Volland, JP ;
Fauchere, JL .
ANALYTICAL BIOCHEMISTRY, 1996, 234 (02) :126-141
[6]  
BRAY AM, 1995, TETRAHEDRON LETT, V36, P5081
[7]   A TRANSITION-STATE ANALOG INHIBITOR COMBINATORIAL LIBRARY [J].
CAMPBELL, DA ;
BERMAK, JC ;
BURKOTH, TS ;
PATEL, DV .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (19) :5381-5382
[8]  
CHAKRAVARTI BJ, 1996, IMMUNOPHARMACOLOGY, V35, P61
[9]   Amino-terminal sequence determinants for substrate recognition by platelet-derived growth factor receptor tyrosine kinase [J].
Chan, PM ;
Keller, PR ;
Connors, RW ;
Leopold, WR ;
Miller, WT .
FEBS LETTERS, 1996, 394 (02) :121-125
[10]  
CHEN JK, 1995, ANGEW CHEM INT EDIT, V34, P935