A convenient catalytic procedure for the highly enantioselective aldol condensation of O-silyldienolates

被引：30

作者：

De Rosa, M ^{[1
]}

Acocelli, MR ^{[1
]}

Villano, R ^{[1
]}

Soriente, A ^{[1
]}

Scettri, A ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Chim, I-84081 Baronissi, Salerno, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 17期

关键词：

D O I：

10.1016/S0957-4166(03)00494-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In the presence of catalytic amount of chiral Ti(OiPr)(4)/BINOL (0.08 equiv.) the asymmetric aldol condensation of 6-methyl-4H-[1,3]-dioxin-4-one-derived silyloxydienes takes place in high yields and enantiomeric excesses with aromatic. heteroaromatic, Unsaturated and aliphatic aldehydes. Notable amplification of enantiomeric excesses have been obtained by using enantioenriched catalytic systems. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：2499 / 2502

页数：4

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