Up-regulation of Endothelin-1 and Endothelin type A receptor genes expression in the heart of broiler chickens versus layer chickens

被引：21

作者：

Hassanpour, Hossein ^{[1
]}

Teshfam, Masood ^{[2
]}

Momtaz, Hassan ^{[3
]}

Brujeni, Gholamreza Nikbakht ^{[4
]}

Shahgholian, Lohrasb ^{[5
]}

机构：

[1] Shahrekord Univ, Dept Basic Sci, Fac Vet Med, Shahrekord, Iran

[2] Islamic Azad Univ, Dept Physiol, Fac Vet Sci, Tehran, Iran

[3] Islamic Azad Univ, Dept Microbiol, Fac Vet Med, Shahrekord Branch, Shahrekord, Iran

[4] Univ Tehran, Dept Immunol, Fac Vet Med, Tehran, Iran

[5] Islamic Azad Univ, Dept Physiol, Fac Vet Med, Shahrekord Branch, Shahrekord, Iran

来源：

RESEARCH IN VETERINARY SCIENCE | 2010年 / 89卷 / 03期

关键词：

Endothelin; Receptor; Gene expression; Broiler; Layer; PULMONARY-HYPERTENSION SYNDROME; TISSUE GROWTH-FACTOR; PROGNOSTIC IMPACT; DISEASE; ASCITES; FAILURE; DYSFUNCTION; ANTAGONISTS; HYPOXIA; LUNGS;

D O I：

10.1016/j.rvsc.2010.04.005

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

090604 [动物药学];

摘要：

To compare Endothelin (ET) production and genes expression of ET-1 and ET(A) receptor (ET(A)R) between broiler and layer chickens during rearing, semi-quantitative RT-PCR and enzyme immunometric assay were performed in the heart ventricles and serum. There were gradual elevations of ET-1 and ET(A)R mRNAs in the left ventricle of broiler and layer chicken groups that were mainly significant (P < 0.05) at 28, 35 and 42 days of age with compared to previous days whereas were not significant between two groups. These gradual elevations of ET-1 and ET(A)R mRNAs were also observed in the right ventricle that were significant (P < 0.05) at 28,35 and 42 days of age in broilers and 42 days of age in layers with compared to previous days. Increasing of these mRNAs in the right ventricle of broiler chickens were significantly (P < 0.05) more than layer chickens at 28, 35 and 42 days. Serum ET in broilers was significantly (P < 0.05) higher than layer chickens at 28 and 42 days of age. It is concluded that circulating ET and cardiac ET-1, ET(A)R genes expression is higher in broiler chickens than in layer chickens particularly after 21 days of age. It is probably that these breed differences make broiler chickens to be more susceptible to Endothelin related-cardiomyopathies such as congestive heart failure and ascites. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：352 / 357

页数：6

共 36 条

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Endothelinrole in vascular disease [J].