Acquired sulphonamide resistance genes in faecal Escherichia coli from healthy children in Bolivia and Peru

被引：41

作者：

Infante, B

Grape, M

Larsson, M

Kristiansson, C

Pallecchi, L

Rossolini, GM

Kronvall, G ^{[1
]}

机构：

[1] Karolinska Inst, Microbiol & Tumor Biol Ctr MTC, SE-17176 Stockholm, Sweden

[2] Karolinska Inst, Dept Publ Hlth Sci, Div Int Hlth IHCAR, SE-17176 Stockholm, Sweden

[3] Univ Siena, Dipartimento Biol Mol, Lab Fisiol & Biotecnol Microrganismi, I-53100 Siena, Italy

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2005年 / 25卷 / 04期

关键词：

sulphonamide resistance; co-trimoxazole; sul; integron; E; coli;

D O I：

10.1016/j.ijantimicag.2004.12.004

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Antimicrobial resistance and sulphonamide resistance determinants were studied in 20 co-trimoxazole resistant Escherichia coli in faecal samples from healthy children in Bolivia and Peru. Methods used were disc diffusion susceptibility tests, PCR, sequence analysis and plasmid conjugation assays. All isolates but one were resistant to at least two different classes of antimicrobials; 19 isolates also carried at least one sul-gene. The most frequent gene was sul2 followed by sul1 and sul3, which was detected in one isolate. This is the first observation of sul3 on the American continent. In conclusion, the high prevalence of sul-genes in this material of faecal commensal E. coli isolates points to a potential role of the faecal flora in the emergence and spread of antimicrobial resistance. (C) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：308 / 312

页数：5

共 25 条

[1]

*APUA, RES ANT RES COMM BAC

[2] High prevalence of acquired antimicrobial resistance unrelated to heavy antimicrobial consumption [J].