Inhibin and ovarian cancer

被引：22

作者：

Burger, HG ^{[1
]}

Baillie, A ^{[1
]}

Drummond, AE ^{[1
]}

Healy, DL ^{[1
]}

Jobling, T ^{[1
]}

Mamers, P ^{[1
]}

Robertson, DM ^{[1
]}

Susil, B ^{[1
]}

Cahir, N ^{[1
]}

Shen, Y ^{[1
]}

Verity, K ^{[1
]}

Fuller, PJ ^{[1
]}

Groome, NP ^{[1
]}

Findlay, JK ^{[1
]}

机构：

[1] Oxford Brookes Univ, Oxford OX3 0BP, England

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1998年 / 39卷 / 1-2期

关键词：

inhibin; activin; ovarian cancer; granulosa cell tumour; mucinous tumour; serous cystadenocarcinoma; CA125;

D O I：

10.1016/S0165-0378(98)00014-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumours and in the majority of postmenopausal women with mucinous ovarian cancers. The present manuscript confirms these findings in a larger group of postmenopausal women. Immunohistochemistry for the inhibin alpha, beta(A) and beta(B) subunits shows predominantly epithelial staining in granulosa cell tumours and in the majority of mucinous cancers. Serous cystadenocarcinomas also frequently show positive staining. Studies seeking to identify G alpha(i-2) or FSH receptor mutations have provided negative results in contrast to other reports. Further studies of the roles of the inhibin-related family of peptides in ovarian cancer diagnosis and monitoring are clearly indicated. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：77 / 87

页数：11

共 23 条

[1] MUTATION IN THE FOLLICLE-STIMULATING-HORMONE RECEPTOR GENE CAUSES HEREDITARY HYPERGONADOTROPIC OVARIAN FAILURE [J].