SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors

被引：121

作者：

Liu, LP

Stelmach, JE

Natarajan, SR

Chen, MH

Singh, SB

Schwartz, CD

Fitzgerald, CE

O'Keefe, SJ

Zaller, DM

Schmatz, DM

Doherty, JB

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Inflamat Res, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 22期

关键词：

D O I：

10.1016/j.bmcl.2003.08.059

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Development for a class of potent 3,4-dihydropyrido(3,2-d)pyrimidone inhibitors of p38a MAP kinase is described. Modification of N-1 aryl and C-6 arylsulfide in 3,4-dihydropyrido (3,2-d)pyrimidone analogues for the interaction with the hydrophobic pockets in p38 active site is also discussed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3979 / 3982

页数：4

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