Flow injection potentiometric determination of bismuth(III) in anti-acid formulations

被引:17
作者
Teixeira, MFS [1 ]
Fatibello-Filho, O [1 ]
机构
[1] Univ Fed Sao Carlos, Dept Quim, Ctr Ciencias Exatas & Tecnol, Grp Quim Analit, BR-13560970 Sao Carlos, SP, Brazil
关键词
bismuth(III) tubular ion-selective electrode; ethylenediamintetraacetate; anti-acid formulations; flow injection;
D O I
10.1016/S0378-5173(01)00683-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A flow injection potentiometric procedure is proposed for determining bismuth(III) in anti-acid formulations. In this work, a tubular electrode coated with an ion-pair formed between [Bi(EDTA)](-) and tricaprylylmethylammonium cation (Aliquat 336) in a poly(vinylchloride) (PVC) was constructed and used in a single channel flow injection system. The effect of membrane composition, pH and flow injection parameter over the Bi(III) tubular electrode response (slope (mV/decade)) was initially evaluated in quintuplicate in 0.5 mol l(-1) EDTA solution as carrier. The best response (-59.6 +/- 0.9 mV/decade) was attained with the 5% m/m ion-pair; 65% m/m o-nitrophenyl octyl ether (o-NPOE) and 30% m/m PVC in pH 6-9. The electrode showed a linear response to E (mV) versus log [Bi(EDTA)](-) in the bismuth(III) concentration range from 2.0 x 10(-5) to 1.0 x 10(-2) mol l(-1) and a useful lifetime of at least 5 months (more than 1000 determinations for each polymeric membrane). The detection limit was 1.2 x 10(-5) mol l(-1) and the R.S.D. was less than 2.0% for a solution containing 5.0 x 10(-4) mol l(-1) bismuth(III) (n = 10). Several species such as Cd(II), Mn(II), Ni(II), Zn(II), Co(II), Cu(II). Mg(II), Cr(III) and AI(III) at 1.0 x 10(-3) mol l(-1) concentration in 0.5 mol l(-1) EDTA solution did not cause any interference. The frequency rate was 90 determinations per hour and the results obtained for bismuth(III) in anti-acid formulations using this flow procedure and those obtained using a spectrophotometric procedure are in agreement at the 95% confidence level. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:115 / 121
页数:7
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