Surfactant protein A (SP-A) gene targeted mice

被引：85

作者：

Korfhagen, TR ^{[1
]}

LeVine, AM ^{[1
]}

Whitsett, JA ^{[1
]}

机构：

[1] Childrens Hosp Res Fdn, Div Pulm Biol, Cincinnati, OH 45229 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1998年 / 1408卷 / 2-3期

关键词：

D O I：

10.1016/S0925-4439(98)00075-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mice lacking surfactant protein A (SP-A) mRNA and protein in vivo were generated using gene targeting techniques. SP-A (-/-) mice have normal levels of SP-B, SP-C and SP-D mRNA and protein and survive and breed normally in vivarium conditions. Phospholipid composition, secretion and clearance, and incorporation of phospholipid precursors are normal in the SP-A (-/-) mice. Lungs of SP-A (-/-) mice have markedly decreased tubular myelin figures and clear Group B streptococci and Pseudomonas aeruginosa less efficiently than SP-A wild type mice. These studies of SP-A (-/-) mice demonstrate that SP-A has an important role in the innate immune system of the lung in vivo. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：296 / 302

页数：7

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