Independent modes of natural killing distinguished in mice lacking Lag3

被引：138

作者：

Miyazaki, T ^{[1
]}

Dierich, A ^{[1
]}

Benoist, C ^{[1
]}

Mathis, D ^{[1
]}

机构：

[1] CU STRASBOURG,STRASBOURG,FRANCE

来源：

SCIENCE | 1996年 / 272卷 / 5260期

关键词：

D O I：

10.1126/science.272.5260.405

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The LAG3 protein has several features in common with CD4, suggesting that it may be important in controlling T cell reactivity. However, mice with a Lag3 null mutation have now been shown to exhibit a defect in the natural killer cell, rather than the T cell, compartment. Killing of certain tumor targets by natural killer cells from these mice was inhibited or even abolished, whereas lysis of cells displaying major histocompatibility complex class I disparities remained intact. It appears that LAG3 is a receptor or coreceptor that defines different modes of natural killing.

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页码：405 / 408

页数：4

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