Toward an AIDS vaccine

被引：268

作者：

Walker, Bruce D. ^{[1
,2
,3
]}

Burton, Dennis R. ^{[4
]}

机构：

[1] Massachusetts Gen Hosp, Boston, MA 02129 USA

[2] Harvard Univ, Sch Med, Boston, MA 02129 USA

[3] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[4] Scripps Res Inst, La Jolla, CA 92037 USA

来源：

SCIENCE | 2008年 / 320卷 / 5877期

关键词：

D O I：

10.1126/science.1152622

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A quarter century of scientific discovery has been applied to developing an AIDS vaccine, yet this goal remains elusive. Specific characteristics of the virus, including the extreme genetic variability in circulating viral isolates worldwide, biological properties of HIV that impede immune attack, and a high mutation rate that allows for rapid escape from adaptive immune responses, render this a huge challenge. However, evidence of protection against AIDS viruses in animal models and control of HIV in humans under certain circumstances, together with scientific advances in understanding disease pathogenesis, provide a strong rationale and objective paths to continue the pursuit of an effective AIDS vaccine to stem the global epidemic.

引用

页码：760 / 764

页数：5

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