The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms

被引：118

作者：

Dayem, Ahmed Abdal ^{[1
]}

Choi, Hye Yeon ^{[1
]}

Yang, Gwang-Mo ^{[1
]}

Kim, Kyeongseok ^{[1
]}

Saha, Subbroto Kumar ^{[1
]}

Cho, Ssang-Goo ^{[1
]}

机构：

[1] Konkuk Univ, Incurable Dis Anim Model & Stem Cell Inst IDASI, Dept Stem Cell & Regenerat Biotechnol, Seoul 05029, South Korea

来源：

NUTRIENTS | 2016年 / 8卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

polyphenols; breast cancer; anti-cancer activity; autophagy; apoptosis; cancer stem cells; NF-KAPPA-B; RESVERATROL-INDUCED APOPTOSIS; GREEN TEA POLYPHENOLS; EPITHELIAL-MESENCHYMAL TRANSITION; ESTROGEN-RECEPTOR MODULATORS; I CLINICAL-TRIAL; OXIDATIVE STRESS; PROSTATE-CANCER; DOWN-REGULATION; CYCLE ARREST;

D O I：

10.3390/nu8090581

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The high incidence of breast cancer in developed and developing countries, and its correlation to cancer-related deaths, has prompted concerned scientists to discover novel alternatives to deal with this challenge. In this review, we will provide a brief overview of polyphenol structures and classifications, as well as on the carcinogenic process. The biology of breast cancer cells will also be discussed. The molecular mechanisms involved in the anti-cancer activities of numerous polyphenols, against a wide range of breast cancer cells, in vitro and in vivo, will be explained in detail. The interplay between autophagy and apoptosis in the anti-cancer activity of polyphenols will also be highlighted. In addition, the potential of polyphenols to target cancer stem cells (CSCs) via various mechanisms will be explained. Recently, the use of natural products as chemotherapeutics and chemopreventive drugs to overcome the side effects and resistance that arise from using chemical-based agents has garnered the attention of the scientific community. Polyphenol research is considered a promising field in the treatment and prevention of breast cancer.

引用

页数：37

共 342 条

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