Clinical and biochemical determinants of plasma lipid peroxide levels in type 2 diabetes

被引：5

作者：

Lawrence, JR

Campbell, GR

Barrington, H

Malcolm, EA

Brennan, G

Wiles, DH

Paterson, JR

机构：

[1] Dumfries & Galloway Royal Infirm, Dept Med, Dumfries DG1 4AP, Scotland

[2] Dumfries & Galloway Royal Infirm, Dept Biochem, Dumfries DG1 4AP, Scotland

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 1998年 / 35卷

关键词：

HbAl; glycaemic control; vascular disease ranking; antioxidant vitamin levels;

D O I：

10.1177/000456329803500307

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The enhanced risk and increased severity of atheroma in diabetes is well recognized but, as yet, incompletely explained. A cross-sectional study of vascular disease risk factors in a group of type 2 diabetic patients from South West Scotland has revealed an association between glycaemic control, assessed by HbAl level and plasma lipid peroxides measured by a specific high-performance liquid chromatography method. Duration of diabetes appeared to be a subsidiary contributor to lipid peroxidation. We suggest this evidence supports the importance of glycaemic control in modulating glyco-oxidative mechanisms probably crucial to production of diabetic complications. Atherosclerosis prevention in diabetes may hinge on exemplary simultaneous control of both hyperglycaemia and hyperlipidaemia.

引用

页码：387 / 392

页数：6

共 25 条

[1] The effect of dietary treatment on lipid peroxidation and antioxidant status in newly diagnosed noninsulin dependent diabetes [J].