A model for cGMP signal transduction in Dictyostelium in perspective of 25 years of cGMP research

被引：28

作者：

Bosgraaf, L ^{[1
]}

Van Haastert, PJM ^{[1
]}

机构：

[1] Univ Groningen, Dept Biochem, NL-9747 AG Groningen, Netherlands

来源：

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY | 2002年 / 23卷 / 7-8期

关键词：

D O I：

10.1023/A:1024431813040

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The chemoattactant mediated cGMP response of Dictyostelium cells was discovered about twenty-five years ago. Shortly thereafter, guanylyl cyclases, cGMP-phosphodiesterases and cGMP-binding proteins were detected already in lysates, but the encoding genes were discovered only very recently. The deduced proteins appear to be very different from proteins with the same function in metazoa. In this review we discuss these new findings in perspective of the previously obtained biochemical and functional data on cGMP in Dictyostelium.

引用

页码：781 / 791

页数：11

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