A novel preparation method for polymeric microparticles without the use of organic solvents

被引：118

作者：

Franssen, O ^{[1
]}

Hennink, WE ^{[1
]}

机构：

[1] Univ Utrecht, Groningen Utrecht Inst Drug Explorat, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3508 TB Utrecht, Netherlands

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1998年 / 168卷 / 01期

关键词：

microparticle; hydrogel; dextran; poly(ethylene glycol); aqueous emulsion; polymer-polymer immiscibility;

D O I：

10.1016/S0378-5173(98)00071-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Microparticles (microcapsules and microspheres) of different chemical compositions (methacrylated dextran, methacrylated poly(ethyleneglycol) and gelatin) were prepared using a novel emulsion technique based on polymer-polymer immiscibility in aqueous solutions. The effect of polymer chemical composition and crosslink density on the properties of the microspheres was evaluated. Microparticles with a volume mean diameter ranging from 2.5 to 25 mu m could be prepared in a reproducible way. Scanning electron microscopy revealed that non-porous and spherical particles were obtained for all preparations. Microcapsules with a single core were prepared using a double emulsion technology, based on the same principle of polymer-polymer immiscibility. These results demonstrate that this new emulsion technique without organic solvents can be used for the preparation of well-defined microparticles differing in size, morphology and chemical composition. (C) 1993 Elsevier Science E.V. All rights reserved.

引用

页码：1 / 7

页数：7

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