A pilot study of dehydroepiandrosterone sulfate in myotonic dystrophy

被引：42

作者：

Sugino, M ^{[1
]}

Ohsawa, N ^{[1
]}

Ito, T ^{[1
]}

Ishida, S ^{[1
]}

Yamasaki, H ^{[1
]}

Kimura, F ^{[1
]}

Shinoda, K ^{[1
]}

机构：

[1] Osaka Med Coll, Dept Internal Med 1, Takatsuki, Osaka 5698686, Japan

来源：

NEUROLOGY | 1998年 / 51卷 / 02期

关键词：

D O I：

10.1212/WNL.51.2.586

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied the effect of TV administration of a dehydroepiandrosterone sulfate (DHEAS) preparation (200 mg/day for 8 weeks) in 11 patients with myotonic dystrophy (MyD). After DHEAS, activities of daily Living improved, muscle strength increased, and myotonia decreased. Conduction block and premature beats also improved in the four patients with cardiac involvement. This pilot study may provide a rationale for a controlled study of DHEAS in MyD.

引用

页码：586 / 589

页数：4

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