The role of mammary stroma in modulating the proliferative response to ovarian hormones in the normal mammary gland

被引：71

作者：

Woodward, TL ^{[1
]}

Xie, JW ^{[1
]}

Haslam, SZ ^{[1
]}

机构：

[1] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 1998年 / 3卷 / 02期

关键词：

epithelial-stromal interactions; mammary gland development; ductal morphogenesis; epidermal growth factor; insulin-like growth factor; hepatocyte growth factor; fibroblast growth factor; estrogen; progesterone; extracellular matrix;

D O I：

10.1023/A:1018738721656

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Postnatal mammary gland development is highly dependent on the ovarian steroids, estrogen and progesterone. However, evidence from both in vitro and in vivo studies indicates that steroid-induced development occurs indirectly, requiring stromal cooperation in epithelial proliferation and morphogenesis. Stromal cells appear to influence epithelial cell behavior by secretion of growth factors and/or by altering the composition of the extracellular matrix in which epithelial cells reside. This review will discuss the requirement for stromal tissue in modulating proliferative responses to ovarian hormones during postnatal development and the potential role of the EGF IGF, HGF and FGF(3) growth factor families. Additionally, the roles of extracellular matrix proteins, including fibronectin, collagens and laminin, will be summarized.

引用

页码：117 / 131

页数：15

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