Inflammatory bowel disease: Genetic and epidemiologic considerations

被引：64

作者：

Cho, Judy H. ^{[1
]}

机构：

[1] Yale Univ, Ctr Inflammatory Bowel Dis, New Haven, CT 06519 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 03期

关键词：

Crohn's disease; ulcerative colitis; interleukin; 23; autophagy; complex genetics;

D O I：

10.3748/wjg.14.338

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Genome-wide association studies have firmly established that many genomic loci contribute to inflammatory bowel disease, especially in Crohn's disease. These studies have newly-established the importance of the interleukin 23 and autophagy pathways in disease pathogenesis. Future challenges include: (1) the establishment of precisely causal alleles, (2) definition of altered functional outcomes of associated and causal alleles and (3) integration of genetic findings with environmental factors. (c) 2008 WJG. All rights reserved.

引用

页码：338 / 347

页数：10

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