HOTAIR: an oncogenic long non-coding RNA in different cancers

被引：404

作者：

Hajjari, Mohammadreza ^{[1
]}

Salavaty, Abbas ^{[1
]}

机构：

[1] Shahid Chamran Univ Ahvaz, Fac Sci, Dept Genet, Ahvaz 613363337, Iran

来源：

CANCER BIOLOGY & MEDICINE | 2015年 / 12卷 / 01期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; INDEPENDENT PROGNOSTIC MARKER; SQUAMOUS-CELL CARCINOMA; POOR-PROGNOSIS; UP-REGULATION; INHIBITS PROLIFERATION; ENDOMETRIAL CARCINOMA; LINCRNA HOTAIR; LNCRNA HOTAIR; STEM-CELLS;

D O I：

10.7497/j.issn.2095-3941.2015.0006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Long non-coding RNAs (lncRNAs) refer to a group of RNAs that are usually more than 200 nucleotides and are not involved in protein generation. Instead, lncRNAs are involved in different regulatory processes, such as regulation of gene expression. Different lncRNAs exist throughout the genome. LncRNAs are also known for their roles in different human diseases such as cancer. HOTAIR is an lncRNA that plays a role as an oncogenic molecule in different cancer cells, such as breast, gastric, colorectal, and cervical cancer cells. Therefore, HOTAIR expression level is a potential biomarker for diagnostic and therapeutic purposes in several cancers. This RNA takes part in epigenetic regulation of genes and plays an important role in different cellular pathways by interacting with Polycomb Repressive Complex 2 (PRC2). In this review, we describe the molecular function and regulation of HOTAIR and its role in different types of cancers.

引用

页码：1 / 9

页数：9

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