Flavin-oligonucleotide conjugates:: sequence specific photocleavage of DNA

被引：17

作者：

Frier, C

Mouscadet, JF

Décout, JL

Auclair, C

Fontecave, M

机构：

[1] UFR Pharm, Chim Bioorgan Lab, CNRS EP 811, F-38706 La Tronche, France

[2] Inst Gustave Roussy, CNRS UMR 1772, PRII 39, F-94805 Villejuif, France

[3] Univ Grenoble 1, Lab Chim & Biochim, Ctr Redox Biol, DBMS,CEA,CNRS, F-38054 Grenoble, France

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 22期

关键词：

D O I：

10.1039/a806119j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A flavin-oligonucleotide conjugate forms a stable triple helix with a double-stranded DNA sequence of HIV-1, and selectively photocleaves it at the 3'-G of a GG doublet located 7 bases away from the flavin position.

引用

页码：2457 / 2458

页数：2

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