Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists

被引：18

作者：

Zhao, HY ^{[1
]}

Xi, ZL ^{[1
]}

Patel, JR ^{[1
]}

Nelson, LTJ ^{[1
]}

Liu, B ^{[1
]}

Szczepankiewicz, BG ^{[1
]}

Schaefer, VG ^{[1
]}

Falls, HD ^{[1
]}

Kaszubska, W ^{[1
]}

Collins, CA ^{[1
]}

Sham, HL ^{[1
]}

Liu, G ^{[1
]}

机构：

[1] Abbott Labs, Metab Dis Res, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 07期

关键词：

ghrelin; antagonist; SAR;

D O I：

10.1016/j.bmcl.2005.02.026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-activity relationship studies on a series of tetralin carboxamide growth hormone secretagogue receptor (GHS-R) antagonists are discussed. It was found that certain 2-alkoxycarbonylamino substituted tetralin carboxamides are potent, selective, and orally bioavailable GHS-R antagonists. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1825 / 1828

页数：4

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