The relation between glutamine and the immunodepression observed in exercise

被引:33
作者
Castell, LM [1 ]
Newsholme, EA [1 ]
机构
[1] Univ Oxford, Dept Biochem, Oxford, England
关键词
amino acids; glutamine; exhaustive exercise; immunodepression;
D O I
10.1007/s007260170065
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glutamine is the most abundant amino acid in the body. It is an important fuel for some key cells of the immune system. Both the plasma concentration of glutamine and the functional ability of immune cells in the blood are decreased after prolonged, exhaustive exercise. Glutamine feeding has had beneficial effects in clinical situations, and the provision of glutamine after intensive exercise has decreased the incidence of infections, particularly of upper respiratory tract infections. However, the precise effect of glutamine on immunodepression in this situation is not yet established.
引用
收藏
页码:49 / 61
页数:13
相关论文
共 62 条
[1]  
ARDAWI MSM, 1985, ESSAYS BIOCHEM, V21, P1
[2]   GLUTAMINE-METABOLISM IN LYMPHOCYTES OF THE RAT [J].
ARDAWI, MSM ;
NEWSHOLME, EA .
BIOCHEMICAL JOURNAL, 1983, 212 (03) :835-842
[3]   MUSCLE AND PLASMA AMINO-ACIDS FOLLOWING INJURY - INFLUENCE OF INTERCURRENT INFECTION [J].
ASKANAZI, J ;
CARPENTIER, YA ;
MICHELSEN, CB ;
ELWYN, DH ;
FURST, P ;
KANTROWITZ, LR ;
GUMP, FE ;
KINNEY, JM .
ANNALS OF SURGERY, 1980, 192 (01) :78-85
[4]  
BASSIT RA, 1999, IN PRESS MED SCI SPO
[5]   LYMPHOCYTE SUBSET CHANGES DURING ACUTE MAXIMAL EXERCISE [J].
BERK, LS ;
NIEMAN, D ;
TAN, SA ;
NEHLSENCANNARELLA, S ;
KRAMER, J ;
EBY, WC ;
OWENS, M .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1986, 18 (06) :706-706
[6]   INFECTION IN ATHLETES [J].
BRENNER, IKM ;
SHEK, PN ;
SHEPHARD, RJ .
SPORTS MEDICINE, 1994, 17 (02) :86-107
[7]  
BRODAN V, 1986, EUR J APPL PHYSL, V35, P69
[8]  
Castell LM, 1997, EUR J APPL PHYSIOL O, V75, P47
[9]   Does glutamine have a role in reducing infections in athletes? [J].
Castell, LM ;
Poortmans, JR ;
Newsholme, EA .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, 1996, 73 (05) :488-490
[10]   Glutamine and the effects of exhaustive exercise upon the immune response [J].
Castell, LM ;
Newsholme, EA .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1998, 76 (05) :524-532