Gini coefficient: A new way to express selectivity of kinase inhibitors against a family of kinases

被引：164

作者：

Graczyk, Piotr P. ^{[1
]}

机构：

[1] UCL, Eisai London Res Labs Ltd, Dept Med Chem, London WC1E 6BT, England

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 50卷 / 23期

关键词：

D O I：

10.1021/jm070562u

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel application of the Gini coefficient for expressing selectivity of kinase inhibitors against a panel of kinases is proposed. This has been illustrated using single-point inhibition data for 40 commercially available kinase inhibitors screened against 85 kinases. Nonselective inhibitors are characterized by Gini values close to zero (Staurosporine, Gini 0.150). Highly selective compounds exhibit Gini values close to 1 (PD184352 Gini 0.905). The relative selectivity of inhibitors does not depend on the ATP concentration.

引用

页码：5773 / 5779

页数：7

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