Human disease: Calcium signaling in polycystic kidney disease

被引：76

作者：

Somlo, S

Ehrlich, B

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Dept Genet, New Haven, CT USA

[3] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT USA

[4] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0960-9822(01)00193-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polycystic kidney disease results from loss of function of either of two novel proteins, polycystin-1 or polycystin-2, Recent studies show that intracellular calcium signaling is important in kidney development, and define defects in this signaling pathway as the basis of cyst formation in polycystic kidney disease.

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收藏

页码：R356 / R360

页数：5

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