Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk

被引：10

作者：

Cakmakoglu, Bedia Agachan ^{[1
]}

Attar, Rukset ^{[2
]}

Kahraman, Ozlem Timirci ^{[1
]}

Dalan, Altay Burak ^{[1
]}

Iyibozkurt, Ahmet Cem ^{[3
]}

Karateke, Ates ^{[4
]}

Attar, Erkut ^{[3
]}

机构：

[1] Istanbul Univ, Expt Med Res Inst, Dept Mol Med, TR-34390 Istanbul, Turkey

[2] Yeditepe Univ Hosp, Dept Obstet & Gynecol, Istanbul, Turkey

[3] Istanbul Univ, Istanbul Med Sch, Dept Obstet & Gynecol, TR-34390 Istanbul, Turkey

[4] Zeynep Kamil Res & Training Hosp, Istanbul, Turkey

来源：

MOLECULAR BIOLOGY REPORTS | 2011年 / 38卷 / 05期

关键词：

Cox-2; Epithelial ovarian carcinoma; Polymorphism; NITRIC-OXIDE SYNTHASE; MESSENGER-RNA EXPRESSION; PROGNOSTIC-SIGNIFICANCE; COLORECTAL-CANCER; LUNG-CARCINOMA; GROWTH-FACTOR; POLYMORPHISM; ADENOCARCINOMAS; ANGIOGENESIS; ASSOCIATION;

D O I：

10.1007/s11033-010-0458-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In this study, we aimed to investigate a possible association of the COX-2 polymorphisms (-765G -> C and -1195A -> G) and with the risk of developing epithelial ovarian carcinoma (EOC). COX-2 gene polymorphisms was investigated in 111 healthy women and 57 patients with EOC. Individuals who had -765 CG, -1195 AA genotype, and -765 C allele had increased risk for ovarian carcinoma (P < 0.01) and individuals with -765 GG, -1195 AG genotypes and -1195 G allele seem to be protected from ovarian carcinoma (P < 0.01). Haplotype analysis confirmed the association of COX-2 gene variants with ovarian carcinoma and revealed that the frequencies of -765C: -1195A haplotype frequencies was significantly higher in patients as compared with those of controls (P = 0.048). We state that there appears to be a modulating role for the COX-2 -1195A -> G and -765G -> C polymorphisms in the development of EOC. To the best of our knowledge, this is the first study to show such an association.

引用

页码：3481 / 3486

页数：6

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