An entropically efficient supramolecular inhibition strategy for Shiga toxins

被引：25

作者：

Kitov, Pavel I. ^{[1
]}

Lipinski, Tomasz ^{[1
]}

Paszkiewicz, Eugenia ^{[1
]}

Solomon, Dmitry ^{[1
]}

Sadowska, Joanna M. ^{[1
]}

Grant, Gordon A. ^{[1
]}

Mulvey, George L. ^{[2
]}

Kitova, Elena N. ^{[1
]}

Klassen, John S. ^{[1
]}

Armstrong, Glen D. ^{[2
]}

Bundle, David R. ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

[2] Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 04期

关键词：

aggregation; biological activity; drug design inhibitors; supramolecular chemistry;

D O I：

10.1002/anie.200704064

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A compact heterobifunctional ligand devoid of a linker between binding functionalities induces a supramolecular assembly between two pentameric proteins, Shiga toxin (blue) and serum amyloid P component, a human serum protein (turquoise). The use of an endogenous protein as a template brings about a 10 000-fold enhancement of ligand activity. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：672 / 676

页数：5

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