A rot mutation restores parental virulence to an agr-null Staphylococcus aureus strain in a rabbit model of endocarditis

被引：24

作者：

McNamara, PJ

Bayer, AS

机构：

[1] Univ Wisconsin, Dept Med Microbiol & Immunol, Sch Med, Madison, WI 53706 USA

[2] Univ Calif Los Angeles, LA Biomed Res Inst, Torrance, CA 90502 USA

[3] Univ Calif Los Angeles, Geffen Sch Med, Los Angeles, CA 90024 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 06期

关键词：

D O I：

10.1128/IAI.73.6.3806-3809.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mutations in rot restore in vitro toxin production to agr-negative strains of Staphylococcus aureus. We show that a rot mutation returns wild-type virulence to an agr mutant, as measured in experimental endocarditis infections by target organ bacterial counts. Implications of our data are discussed in terms of agr antagonist strategies.

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收藏

页码：3806 / 3809

页数：4

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