Image guided particle therapy in CNAO room 2: Implementation and clinical validation

被引：31

作者：

Fattori, G. ^{[1
]}

Riboldi, M. ^{[1
]}

Pella, A. ^{[2
]}

Peroni, M. ^{[1
]}

Cerveri, P. ^{[1
]}

Desplanques, M. ^{[1
,2
]}

Fontana, G. ^{[2
]}

Tagaste, B. ^{[2
]}

Valvo, F. ^{[2
]}

Orecchia, R. ^{[2
,3
]}

Baroni, G. ^{[1
,2
]}

机构：

[1] Politecn Milan, I-20133 Milan, Italy

[2] CNAO, I-27100 Pavia, Italy

[3] IEO, I-20141 Milan, Italy

来源：

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS | 2015年 / 31卷 / 01期

关键词：

IGRT; Image registration; CBCT; Optical imaging; Accuracy measurement; Robotic imaging; ION-BEAM THERAPY; QUALITY-ASSURANCE; PATIENT; LOCALIZATION; RADIOTHERAPY; MOTION; TRACKING; MARGINS; REMOTE; SYSTEM;

D O I：

10.1016/j.ejmp.2014.10.075

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

In this contribution we describe the implementation of a novel solution for image guided particle therapy, designed to ensure the maximal accuracy in patient setup. The presented system is installed in the central treatment room at Centro Nazionale di Adroterapia Oncologica (CNAO, Italy), featuring two fixed beam lines (horizontal and vertical) for proton and carbon ion therapy. Treatment geometry verification is based on robotic in-room imaging acquisitions, allowing for 2D/3D registration from double planar kV-images or 3D/3D alignment from cone beam image reconstruction. The calculated six degrees-of-freedom correction vector is transferred to the robotic patient positioning system, thus yielding automated setup error compensation. Sub-millimetre scale residual errors were measured in absolute positioning of rigid phantoms, in agreement with optical-and laser-based assessment. Submillimetre and sub-degree positioning accuracy was achieved when simulating setup errors with anthropomorphic head, thorax and pelvis phantoms. The in-house design and development allowed a high level of system customization, capable of replicating the clinical performance of commercially available products, as reported with preliminary clinical results in 10 patients. (C) 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

引用

页码：9 / 15

页数：7

共 32 条

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Is it necessary to plan with safety margins for actively scanned proton therapy? [J].