Endo-xenobiotic crosstalk and the regulation of cytochromes P450

被引：14

作者：

Meyer, Urs A. ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

DRUG METABOLISM REVIEWS | 2007年 / 39卷 / 2-3期

关键词：

cytochrome P450; constitutive androstane receptor; pregnane X receptor; heme; AMP-activated protein kinase;

D O I：

10.1080/03602530701498737

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Evolution has provided organisms with an elaborate defense system against foreign compounds and against the accumulation of potentially toxic endogenous molecules, e.g. bile acids. Cytochromes P450 represent an important group of enzymes in this system. This article describes experiments started in the 1970's in Dallas on the coordination of heme and cytochrome P450 synthesis and how these studies evolved over the years into a concept of molecular links between xenobiotic metabolism and endogenous pathways of sterol, lipid, bile acid and energy homeostasis.

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页码：639 / 646

页数：8

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