Lysophosphatidic acid: receptors, signaling and survival

被引：51

作者：

Swarthout, JT ^{[1
]}

Walling, HW ^{[1
]}

机构：

[1] St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2000年 / 57卷 / 13-14期

关键词：

G-protein-coupled receptors; apoptosis; mitogen; calcium mobilization; smooth muscle contraction; phosphatidylinositol;

D O I：

10.1007/PL00000678

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Though the mitogenic activity of lysophosphatidic acid (LPA) has been well established through classical studies, its mechanism of action was long obscure. Recent identification and cloning of LPA-specific receptors has led to the elucidation of the G-proteins and signaling pathways through which this molecule functions. In addition to its mitogenic properties, recent reports have suggested that LPA may also promote cell survival. This review will summarize the current literature regarding LPA signaling and its role as an antiapoptotic factor.

引用

页码：1978 / 1985

页数：8

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