Mechanism of decarboxylation of 1,3-dimethylorotic acid revisited: Trapping of the reaction intermediate

被引：21

作者：

Nakanishi, MP ^{[1
]}

Wu, WM ^{[1
]}

机构：

[1] San Francisco State Univ, Dept Chem & Biochem, San Francisco, CA 94132 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(98)01331-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The decarboxylation of 1,3-dimethylorotic acid was investigated to study the nature of the reaction intermediate. 6-Benzyl-1,3-dimethyluracil was isolated when the decarboxylation was carried out in benzyl bromide, indicating the involvement of a carbon-6 centered nucleophilic intermediate in the reaction pathway. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6271 / 6272

页数：2

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