From developmental disorder to heritable cancer:: It's all in the BMP/TGF-β family

被引：222

作者：

Waite, KA

Eng, C ^{[1
]}

机构：

[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Div Human Canc Genet, Comprehens Canc Ctr,Human Canc Genet Program, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Div Human Canc Genet, Comprehens Canc Ctr,Clin Canc Genet Program, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Internal Med, Div Human Genet, Columbus, OH 43210 USA

[4] Univ Cambridge, Canc Res UK Human Canc Genet Res Grp, Cambridge CB2 2XZ, England

来源：

NATURE REVIEWS GENETICS | 2003年 / 4卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg1178

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Transforming growth factor-beta (TGF-beta) regulates many cellular processes through complex signal-transduction pathways that have crucial roles in normal development. Disruption of these pathways can lead to a range of diseases, including cancer. Mutations in the genes that encode members of the TGF-beta pathway are involved in vascular diseases as well as gastrointestinal neoplasia. More recently, they have been implicated in Cowden syndrome, which is normally associated with mutations in the phosphatase and tensin homologue gene PTEN. Molecular studies of TGF-beta signalling are now showing why mutations in genes that encode components of this pathway result in inherited cancer and developmental diseases.

引用

页码：763 / 773

页数：11

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