Interferons (IFNs) are key cytokines in both innate and adaptive antiviral immune responses - and viruses counteract IFN action

被引:85
作者
Bonjardim, CA [1 ]
机构
[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, Virus Lab,Grp Transducao Sinal, BR-31310390 Belo Horizonte, MG, Brazil
关键词
interferons; innate antiviral immunity; interferon-regulatory factor; Toll-like receptors;
D O I
10.1016/j.micinf.2005.02.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Interferons (IFNs) are transcriptionally regulated cytokines and key players in the innate antiviral immune response. Upon recognition of a virus, or its molecular patterns, by the Toll-like receptors of dendritic cells (DCs), high levels of IFNs are expressed by these cells. This in turn stimulates DC maturation and the subsequent expression of proinflammatory cytokines and costimulatory molecules, leading to the transition to an adaptive antiviral immunity. Conversely, viruses have developed diverse strategies to counterattack host defenses in order to generate their progenies. (c) 2005 Elsevier SAS. All rights reserved.
引用
收藏
页码:569 / 578
页数:10
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