The new gene DmX from Drosophila melanogaster encodes a novel WD-repeat protein

被引：14

作者：

Kraemer, C ^{[1
]}

Weil, B ^{[1
]}

Christmann, M ^{[1
]}

Schmidt, ER ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Mol Genet Biosafety Res & Consulting, D-55099 Mainz, Germany

来源：

GENE | 1998年 / 216卷 / 02期

关键词：

Chironomus; Caenorhabditis elegans; X chromosome; gene structure;

D O I：

10.1016/S0378-1119(98)00347-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DmX is a novel gene from Drosophila melanogaster located on the X chromosome in region 5D5/6-E1. The molecular analysis of the genomic and cDNA sequences of DmX shows that the gene spans appr. 16 kb and displays a mosaic structure with 15 exons. The 12 kb long DmX transcript is present in Drosophila embryos, larvae and adults of both sexes. The open reading frame of DmX encodes a novel WD-repeat protein, containing at least 30 WD-repeat units. WD-repeat proteins contain a conserved motif of approximately 40 amino acids (aa), usually ending with the dipeptide Trp-Asp (WD). Homologues of the DmX gene exist in other dipteran species, in Caenorhabditis elegans and human, revealing that DmX is an evolutionarily well conserved gene. The inferred DMX amino acid sequence shows also limited, but significant similarity to a yeast ORF with unknown function. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：267 / 276

页数：10

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