Standardized phase angle from bioelectrical impedance analysis as prognostic factor for survival in patients with cancer

被引:120
作者
Paiva, Silvana Iturriet [1 ]
Borges, Lucia R. [1 ]
Halpern-Silveira, Denise [3 ]
Assuncao, M. Cecilia F. [2 ]
Barros, Aluisio J. D. [2 ]
Gonzalez, M. Cristina [1 ]
机构
[1] Univ Catolica Pelotas, Postgrad Program, BR-96090520 Pelotas, RS, Brazil
[2] Univ Fed Pelotas, Postgrad Program, Pelotas, RS, Brazil
[3] Univ Fed Pelotas, Fac Nutr, Pelotas, RS, Brazil
关键词
Cancer; Bioelectrical impedance analysis; Phase angle; Survival; Prognostic marker; Standardized phase angle; POPULATION REFERENCE VALUES; NUTRITIONAL ASSESSMENT; HEMODIALYSIS-PATIENTS; CLINICAL-PRACTICE; DIALYSIS PATIENTS; BODY-MASS; AGE; SEX;
D O I
10.1007/s00520-009-0798-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Phase angle (PA), determined by bioelectrical impedance analysis (BIA), has been considered as a prognostic factor in several clinical conditions. The purpose of this study is to investigate PA, after adjusting for sex and age (standardized phase angle; SPA) as a prognostic factor for survival in cancer patients. A prospective study was conducted in 195 patients before the first chemotherapy course. BIA was performed in all patients and SPA was calculated. The Kaplan-Meier method was used to calculate survival. The Cox regression method was used to evaluate the independent prognostic effect of PA after adjustment for other variables. Patients with SPA < -1.65 had a smaller survival rate than those with SPA a parts per thousand yenaEuro parts per thousand a'1.65 (p < 0.001). Using Cox regression, the mortality rate was higher in patients with SPA < -1.65 (RR 3.12 CI: 2.03-4.79; p < 0.001). After multivariate analysis, patients with PA < -1.65 still presented a higher mortality rate (RR 2.35 CI: 1.41-3.90; p = 0.001). The present study demonstrates that PA, used as SPA, is an independent prognostic indicator in this group of cancer patients receiving chemotherapy treatment even after adjustment for other prognostic variables.
引用
收藏
页码:187 / 192
页数:6
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