Molecular ferries: membrane carriers that promote phospholipid flip-flop and chloride transport

被引:94
作者
Smith, BD [1 ]
Lambert, TN
机构
[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
[2] Univ Notre Dame, Walther Canc Res Ctr, Notre Dame, IN 46556 USA
关键词
D O I
10.1039/b303359g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The facilitated transport of ionic or polar solutes through biological membranes is an essential process for cellular life, and a major technical goal of the pharmaceutical industry. Synthetic receptors with affinities for anions are shown to act as molecular ferries and facilitate the movement of chloride ions and salts across vesicle and cell membranes. A process that competes with chloride transport is phospholipid translocation or flip-flop. This has led to the development of synthetic scramblases that can alter the transmembrane distribution of phospholipids and induce biological responses such as membrane enzyme activation. The facilitated translocation of phospholipids with multi ply-charged head groups, like phosphatidylserine, is a difficult supramolecular challenge that requires a complementary, multitopic receptor with appropriate amphiphilicity.
引用
收藏
页码:2261 / 2268
页数:8
相关论文
共 41 条
[1]   GENERATION OF PROTHROMBIN-CONVERTING ACTIVITY AND THE EXPOSURE OF PHOSPHATIDYLSERINE AT THE OUTER SURFACE OF PLATELETS [J].
BEVERS, EM ;
COMFURIUS, P ;
VANRIJN, JLML ;
HEMKER, HC ;
ZWAAL, RFA .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1982, 122 (02) :429-436
[2]   Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia [J].
Boas, FE ;
Forman, L ;
Beutler, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) :3077-3081
[3]   Structure/activity study of tris(2-aminoethyl)amine-derived translocases for phosphatidylcholine [J].
Boon, JM ;
Lambert, TN ;
Smith, BD ;
Beatty, AM ;
Ugrinova, V ;
Brown, SN .
JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (07) :2168-2174
[4]   Facilitated phospholipid translocation across vesicle membranes using low-molecular-weight synthetic flippases [J].
Boon, JM ;
Smith, BD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (50) :11924-11925
[5]   Synthetic membrane transporters [J].
Boon, JM ;
Smith, BD .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (06) :749-756
[6]   Chemical control of phospholipid distribution across bilayer membranes [J].
Boon, JM ;
Smith, BD .
MEDICINAL RESEARCH REVIEWS, 2002, 22 (03) :251-281
[7]   Facilitated phosphatidylcholine flip-flop across erythrocyte membranes using low molecular weight synthetic translocases [J].
Boon, JM ;
Smith, BD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (26) :6221-6226
[8]  
BOON JM, 2003, IN PRESS J AM CHEM S
[9]   RETRACTED: Structure of MsbA from E-coli:: A homolog of the multidrug resistance ATP binding cassette (ABC) transporters (Retracted Article. See vol 314, pg 1875, 2006) [J].
Chang, G ;
Roth, CB .
SCIENCE, 2001, 293 (5536) :1793-1800
[10]   The dipole potential of phospholipid membranes and methods for its detection [J].
Clarke, RJ .
ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2001, 89 :263-281