Oxidative stress by inorganic arsenic: modulation by thyroid hormones in rat

被引：25

作者：

Allen, T ^{[1
]}

Rana, SVS ^{[1
]}

机构：

[1] Ch Charan Singh Univ, Dept Environm Sci, Meerut 250004, Uttar Pradesh, India

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 2003年 / 135卷 / 02期

关键词：

arsenic; thyroid; lipid peroxidation; redox index; liver; kidney;

D O I：

10.1016/S1532-0456(03)00086-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arsenic toxicity is attributed mainly to lipid peroxidation and oxidative stress. We therefore studied the modulatory effects of thyroid hormones on arsenic toxicity in rat on lipid peroxidation and oxidative stress. Thyroid hormones, through a mechanism unknown at present, inhibit arsenic accumulation in liver and kidney. Mobilization of arsenic apparently diminishes lipid peroxidation and improves reduced glutathione status, two biochemical demands of combating arsenic toxicity. Results are discussed in reference to the effect of thyroid hormones on microsomal metabolism of arsenic. Arsenic is less toxic in hyperthyroid than in hypothyroid rats. A physiological antagonism between arsenic and thyroxine is discussed. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：157 / 162

页数：6

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