Asymmetric acylation with polyethylene glycol-modified Candida cylindracea lipase in homogeneous organic media

被引：9

作者：

Bremen, U ^{[1
]}

Gais, HJ ^{[1
]}

机构：

[1] RHEIN WESTFAL TH AACHEN,INST ORGAN CHEM,D-52056 AACHEN,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 11期

关键词：

D O I：

10.1016/0957-4166(96)00398-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学]; 081704 [应用化学];

摘要：

MPEG-CCL was prepared by acylation of CCL with MPEG-OCH2CO-OSu and characterized by FPLC and PAGE. MPEG-CCL is soluble in benzene and it retains 31% of the activity of CCL. In benzene MPEG-CCL has a significantly higher activity than CCL. The enantioselectivities of CCL- and MPEG-CCL-catalyzed acylations are similar. MPEG-CCL-catalyzed acylations with isopropenyl methoxyacetate and hydrolyses of methoxyacetates have especially high rates. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：3063 / 3066

页数：4

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