Synthesis of a versatile tetrasaccharide of sialyl Le(X) and Le(X) antigens

被引：16

作者：

Chowdhury, US

机构：

来源：

TETRAHEDRON | 1996年 / 52卷 / 39期

关键词：

D O I：

10.1016/0040-4020(96)00759-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzyl 4-O-[2,4,6-tri-O-benzyl-3-O-(4-methoxybenzyl)-beta-D-galactopyranosyl]-2,3,6-tri-O-benzyl-beta-D-glucopyranoside (4) was synthesised from benzyl lactoside (2) via regioselective protection of 3'-OH with 4-methoxybenzyl group. Oxidative deprotection of 4 afforded the valuable acceptor 5, The trisaccharide 7 was obtained through coupling of 5 and phenyl 2-deoxy-3,4,6-tri-O-acetyl-2-phthalimido-1-thio-beta-D-glucopyranoside (6). The desired tetrasaccharide 1 was built up through fucosylation of the benzylidene derivative 11 obtained from 7. Copyright (C) 1996 Published by Elsevier Science Ltd

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页码：12775 / 12782

页数：8

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