Surgical site infections in cardiac surgery:: microbiology

被引:31
作者
Soderquist, Bo [1 ]
机构
[1] Orebro Univ Hosp, Dept Clin Microbiol, Orebro, Sweden
[2] Orebro Univ Hosp, Dept Infect Dis, Orebro, Sweden
关键词
staphylococcal infections; surgical site infection; sternal wound infections; bacterial adhesion; virulence factors;
D O I
10.1111/j.1600-0463.2007.00833.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Coagulase-negative staphylococci (CoNS) are the most common bacteria isolated from infections following cardiac surgery. CoNS display various virulence factors, such as toxins, adhesive proteins and biofilm production. The Staphylococcus epidermidis surface (Ses) protein I and the ica operon encoding the polysaccharide intercellular adhesin (PIA) are discussed in more detail. Although several of these virulence factors are prevalent among CoNS isolates causing sternal wound infections, they do not represent a prerequisite for causing an infection and that emphasizes that host factors may be as important.
引用
收藏
页码:1008 / 1011
页数:4
相关论文
共 22 条
[1]   Mediastinitis after cardiovascular operations: A case-control study of risk factors [J].
Bitkover, CY ;
Gardlund, B .
ANNALS OF THORACIC SURGERY, 1998, 65 (01) :36-40
[2]   Identification and preliminary characterization of cell-wall-anchored proteins of Staphylococcus epidermidis [J].
Bowden, MG ;
Chen, W ;
Singvall, J ;
Xu, Y ;
Peacock, SJ ;
Valtulina, V ;
Speziale, P ;
Höök, M .
MICROBIOLOGY-SGM, 2005, 151 :1453-1464
[3]   Bap, a Staphylococcus aureus surface protein involved in biofilm formation [J].
Cucarella, C ;
Solano, C ;
Valle, J ;
Amorena, B ;
Lasa, I ;
Penadés, JR .
JOURNAL OF BACTERIOLOGY, 2001, 183 (09) :2888-2896
[4]   Biofilms: Survival mechanisms of clinically relevant microorganisms [J].
Donlan, RM ;
Costerton, JW .
CLINICAL MICROBIOLOGY REVIEWS, 2002, 15 (02) :167-+
[5]   Prophylaxis of sternal wound infections with gentamicin-collagen implant: randomized controlled study in cardiac surgery [J].
Eklund, AM ;
Valtonen, M ;
Werkkala, KA .
JOURNAL OF HOSPITAL INFECTION, 2005, 59 (02) :108-112
[6]   The genetics of staphylococcal biofilm formation-will a greater understanding of pathogenesis lead to better management of device-related infection? [J].
Fitzpatrick, F ;
Humphreys, H ;
O'Gara, JP .
CLINICAL MICROBIOLOGY AND INFECTION, 2005, 11 (12) :967-973
[7]   Surface protein adhesins of Staphylococcus aureus [J].
Foster, TJ ;
Höök, M .
TRENDS IN MICROBIOLOGY, 1998, 6 (12) :484-488
[8]   Incidence, microbiological findings, and clinical presentation of sternal wound infections after cardiac surgery with and without local gentamicin prophylaxis [J].
Friberg, O. ;
Svedjeholm, R. ;
Kallman, J. ;
Soderquist, B. .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2007, 26 (02) :91-97
[9]   Local gentamicin reduces sternal wound infections after cardiac surgery:: A randomized controlled trial [J].
Friberg, Ö ;
Svedjeholm, R ;
Söderquist, B ;
Granfeldt, H ;
Vikerfors, T ;
Källman, J .
ANNALS OF THORACIC SURGERY, 2005, 79 (01) :153-162
[10]   Postoperative mediastinitis in cardiac surgery -: microbiology and pathogenesis [J].
Gårdlund, B ;
Bitkover, CY ;
Vaage, J .
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2002, 21 (05) :825-830