On the use of tandem allylic acetate isomerisation and ring-closing metathesis with palladium(0) phosphine complexes and ruthenium benzylidenes as orthogonal catalysts

被引：34

作者：

Braddock, DC ^{[1
]}

Wildsmith, AJ ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 18期

关键词：

Grubbs' catalyst; palladium(0); tricyclohexylphosphine; metathesis; allylic isomerisation;

D O I：

10.1016/S0040-4039(01)00405-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Attempted tandem allylic acetate isomerisation and ring-closing metathesis using combinations of palladium(0)/Grubbs' catalyst/PPh3 led to either allylic isomerisation or ring-closing metathesis but not both in tandem. The effect was traced to deactivation of Grubbs' catalyst by added PPh3 and poisoning of the Pd(0) by the necessarily released PCy3 (Cy=cyclohexyl) from Grubbs' catalyst. Successful tandem isomerisation/ring-closing metathesis was achieved by the use of palladium(0)/PPh3 systems in conjunction with a PCy3 free olefin metathesis catalyst. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3239 / 3242

页数：4

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