Mannich reactions using benzyl azide as a latent N-(phenylamino)methylating agent

被引：20

作者：

Schildknegt, K ^{[1
]}

Agrios, KA ^{[1
]}

Aubé, J ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 42期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(98)01721-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of benzyl azide with triflic acid or titanium tetrachloride effects 1,2-phenyl migration with concomitant liberation of molecular nitrogen. The resulting N-phenyl iminium ion intermediate readily combines with enolizable carbonyl substrates to form Mannich bases. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7687 / 7690

页数：4

共 13 条

[1]

[Anonymous], [No title captured]

[2]

Arend M, 1998, ANGEW CHEM INT EDIT, V37, P1044, DOI 10.1002/(SICI)1521-3773(19980504)37:8<1044::AID-ANIE1044>3.0.CO

[3]

2-E

[4] TICL4-MEDIATED REACTIONS OF ALKYL AZIDES WITH CYCLIC-KETONES [J].