Megathyrin B:: A cytotoxic diterpene from Isodon megathyrsus

被引：6

作者：

Qiu, SX

Sun, HD

Lobkovsky, E

Chai, H

Clardy, I

Farnsworth, NR

Pezzuto, JM

Fong, HHS

机构：

[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[2] Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China

[3] Cornell Univ, Baker Lab, Dept Chem, Ithaca, NY 14853 USA

来源：

PLANTA MEDICA | 1998年 / 64卷 / 08期

关键词：

Isodon megathyrsus; Labiatae; leaves; ent-kaurene diterpene; human cancer lines; cytotoxic activity; 2D-NMR techniques; X-ray crystallography; megathyrin B; electrospray LC/MS;

D O I：

10.1055/s-2006-957567

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the leaves of Isodon megothyrsus, a novel entkaurene diterpene, megathyrin B, was isolated and its structure determined as 1 alpha,7 beta,11 beta,15 beta-tetrahydroxy-ent-7 alpha,20-epoxykaur-16-ene by 1D- and 2D-NMR spectral analysis. Additionally, its stereochemistry was unambiguously assigned by X-ray crystallography. This compound was cytotoxic to the KB and KB-V cell lines.

引用

页码：728 / 731

页数：4

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