Advances and applications of oral cancer basic research

被引：129

作者：

da Silva, Sabrina Daniela ^{[2
,3
]}

Ferlito, Alfio ^{[4
]}

Takes, Robert P. ^{[1
]}

Brakenhoff, Ruud H. ^{[5
]}

Valentin, MeV Dominguez ^{[6
]}

Woolgar, Julia A. ^{[7
,8
]}

Bradford, Carol R. ^{[9
]}

Rodrigo, Juan P. ^{[10
,11
]}

Rinaldo, Alessandra ^{[4
]}

Hier, Michael P. ^{[2
]}

Kowalski, Luiz P. ^{[3
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Otolaryngol Head & Neck Surg, NL-6500 HB Nijmegen, Netherlands

[2] McGill Univ, Jewish Gen Hosp, Dept Otolaryngol Head & Neck Surg, Montreal, PQ H3T 1E2, Canada

[3] Ctr Tratamento & Pesquisa Hosp Canc AC Camargo, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, Brazil

[4] Univ Udine, ENT Clin, I-33100 Udine, Italy

[5] Vrije Univ Amsterdam, Med Ctr, Dept Otolaryngol Head & Neck Surg, Amsterdam, Netherlands

[6] Lund Univ, Dept Oncol, Lund, Sweden

[7] Univ Liverpool, Sch Dent Sci, Liverpool L69 3BX, Merseyside, England

[8] Univ Liverpool, Dent Hosp, Liverpool L69 3BX, Merseyside, England

[9] Univ Michigan, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA

[10] Hosp Univ Cent Asturias, Dept Otolaryngol, Oviedo, Spain

[11] Inst Univ Oncol Principado Asturias, Oviedo, Spain

来源：

ORAL ONCOLOGY | 2011年 / 47卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

Oral cancer; Squamous cell carcinoma; Molecular biology; Cancer research; Advances and applications; SQUAMOUS-CELL CARCINOMA; FATTY-ACID SYNTHASE; GENETICALLY ALTERED FIELDS; AERODIGESTIVE TRACT CANCER; TOLONIUM CHLORIDE RINSE; LYMPH-NODE METASTASIS; OF-THE-LITERATURE; NECK-CANCER; DNA-REPAIR; HUMAN-PAPILLOMAVIRUS;

D O I：

10.1016/j.oraloncology.2011.07.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cancer of the oral cavity accounts for almost 3% of cancer cases in the world. The incidence varies widely reflecting geographic differences in exposure to risk factors. The recent rise in younger age groups and females seen in many countries is of particular concern. Treatment and management of complications, locoregional recurrence and further primary tumors result in high morbidity and mortality especially when the disease is advanced stage at initial diagnosis. Progress in cancer research has provided abundant new knowledge about cellular processes and molecular biology underlying oral carcinogenesis and tumor progression. The present review attempts to summarize the current most widely-used research approaches and their application in the prevention, diagnosis, effective treatment, and improved outcome of oral cancer. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：783 / 791

页数：9

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