Does the Amount of Fat Mass Predict Age-Related Loss of Lean Mass, Muscle Strength, and Muscle Quality in Older Adults?

被引：212

作者：

Koster, Annemarie ^{[1
,2
]}

Ding, Jingzhong ^{[3
]}

Stenholm, Sari ^{[4
,5
]}

Caserotti, Paolo ^{[1
,6
]}

Houston, Denise K. ^{[3
]}

Nicklas, Barbara J. ^{[3
]}

You, Tongjian ^{[7
]}

Lee, Jung Sun ^{[8
]}

Visser, Marjolein ^{[9
,10
]}

Newman, Anne B. ^{[11
]}

Schwartz, Ann V. ^{[12
]}

Cauley, Jane A. ^{[13
]}

Tylavsky, Frances A. ^{[14
]}

Goodpaster, Bret H. ^{[15
]}

Kritchevsky, Stephen B. ^{[3
]}

Harris, Tamara B. ^{[1
]}

机构：

[1] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA

[2] Maastricht Univ, Med Ctr, Sch Publ Hlth & Primary Care CAPHRI, Dept Internal Med, Maastricht, Netherlands

[3] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Sect Gerontol & Geriatr Med,Sticht Ctr Aging, Winston Salem, NC 27103 USA

[4] NIA, Clin Res Branch, Baltimore, MD 21224 USA

[5] Natl Inst Hlth & Welf, Dept Hlth Funct Capacity & Welf, Turku, Finland

[6] Univ So Denmark, Inst Sports Sci & Clin Biomech, Odense, Denmark

[7] SUNY Buffalo, Dept Exercise & Nutr Sci, Buffalo, NY 14260 USA

[8] Univ Georgia, Dept Food & Nutr, Athens, GA 30602 USA

[9] Vrije Univ Amsterdam, Fac Earth & Life Sci, Dept Hlth Sci, Amsterdam, Netherlands

[10] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[11] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA

[12] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[13] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15260 USA

[14] Univ Tennessee, Coll Med, Dept Prevent Med, Memphis, TN USA

[15] Univ Pittsburgh, Med Ctr, Dept Med, Pittsburgh, PA 15260 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2011年 / 66卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Adipose tissue; Muscle mass; Muscle strength; Obesity; Aging; HOMEOSTASIS MODEL ASSESSMENT; BODY-COMPOSITION; PHYSICAL-ACTIVITY; SKELETAL-MUSCLE; ELDERLY-MEN; INSULIN-RESISTANCE; ADIPOSE-TISSUE; SARCOPENIA; OBESITY; HEALTH;

D O I：

10.1093/gerona/glr070

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Background. An excessive amount of adipose tissue may contribute to sarcopenia and may be one mechanism underlying accelerated loss of muscle mass and strength with aging. We therefore examined the association of baseline total body fat with changes in leg lean mass, muscle strength, and muscle quality over 7 years of follow-up and whether this link was explained by adipocytokines and insulin resistance. Methods. Data were from 2,307 men and women, aged 70-79 years, participating in the Health, Aging, and Body Composition study. Total fat mass was acquired from dual energy X-ray absorptiometry. Leg lean mass was assessed by dual energy X-ray absorptiometry in Years 1, 2, 3, 4, 5, 6, and 8. Knee extension strength was measured by isokinetic dynamometer in Years 1, 2, 4, 6, and 8. Muscle quality was calculated as muscle strength divided by leg lean mass. Results. Every SD greater fat mass was related to 1.3 kg more leg lean mass at baseline in men and 1.5 kg in women (p < .01). Greater fat mass was also associated with a greater decline in leg lean mass in both men and women (0.02 kg/year, p < .01), which was not explained by higher levels of adipocytokines and insulin resistance. Larger fat mass was related to significantly greater muscle strength but significantly lower muscle quality at baseline (p < .01). No significant differences in decline of muscle strength and quality were found. Conclusions. High fatness was associated with lower muscle quality, and it predicts accelerated loss of lean mass. Prevention of greater fatness in old age may decrease the loss of lean mass and maintain muscle quality and thereby reducing disability and mobility impairments.

引用

页码：888 / 895

页数：8

共 41 条

[1]

Compendium of Physical Activities: an update of activity codes and MET intensities [J].